The Original Since 1947

Invented by Dr. Jack Masquelier in France,
now available as Flavay®

Pure & Authentic Original
French Maritime Pine Bark Extract
and Vitis Vinifera Grape Seed

60 Years of Research Reveals
Many Health Benefits of Flavay®

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Flavay® is the original scientifically-defined complex of small-cluster (oligomeric) proanthocyanidin molecules discovered, defined and isolated by Dr. Jack Masquelier; validated by the French Ministry of Health, proven safe and effective by human studies, and used worldwide since 1950.

What makes Flavay® superior to other extracts?

Flavay® is the authentic small-cluster proanthocyanidins complex derived from French pine bark and grape seeds—pure and unadulterated —used in the actual experiments by which Dr. Jack Masquelier established the "Radical Scavenger Effect."(1-3)

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More than 60 years of solid scientific research, patents and clinical studies, rigorous manufacturing controls and comprehensive identity testing to safeguard quality and consistency, Flavay® is produced at the same French manufacturing facilities for pharmaceutical over-the-counter and dietary supplement uses worldwide. Flavay® is the name you can trust for pure and unadulterated authentic small-cluster OPCs manufactured in France for over 60 years.

Proanthocyanidin clusters must have a certain molecular size to be effective.

Oligomeric (small-cluster) proanthocyanidins (OPCs) are organic clusters of dimers (2), trimers (3), tetramers (4) and pentamers (5)—and no larger. (Larger clusters are non-nutritive: cannot pass the intestinal tract into the blood and too large to fit between collagen fibrils, and therefore unable to repair decayed collagen.) Dr. Masquelier received several patents for the commercial extraction and isolation of OPCs from pine bark and grape seeds. It is these highly defined complexes in Flavay® that have been subject to intensive biological, toxicological, pharmacological and analytical research; and approved in Europe as over-the-counter medicines. (2-4)

oligomeric small-cluster proanthocyanidins are comprised of catechins, epicatechins, dimers, trimers, tetramers and pentamers ABOVE: OPCs are organic clusters of dimers (2), trimers (3), tetramers (4) and pentamers (5)—and no larger—because larger clusters are non-nutritive. Known as POLYmeric proanthocyanidins (PPCs, or tannins), the larger clusters cannot pass the intestinal tract into the blood and so are non-nutritive. Too large to fit between collagen fibrils, PPCs are unable to repair decayed collagen. (2-4)
sixty years of science

Methods of Action

For more than 60 years this antioxidant complex, now known as Flavay®, has produced stunning health results across Europe. Flavay® is totally safe to use—100% non-toxic and natural. It is well documented that this powerful antioxidant nutrient can benefit many different systems and body parts.

Flavay® has several key actions when consumed:

  • Flavay® is a powerfully effective ANTIOXIDANT that recycles other antioxidants in the body after they have quenched corrosive free radicals which affect many tissues and conditions including cognitive impairment and premature aging. (1-7,18,20,22-31,84,85,87,89)
  • Flavay® helps to regulate the good-bad free radical, NITRIC OXIDE, which is essential for: normal blood circulation, coordinating activity between the immune system and the brain, and modulating communication between brain cells—and is thereby deeply involved in concentration, learning and memory. (5,7,10,14)
  • Flavay® inhibits the release and synthesis of HISTAMINE, a key factor in the promotion of INFLAMMATION; reactions associated with conditions like vascular diseases, allergies, and arthritis. (1-10,77,79,87)
  • Flavay® strengthens and rebuilds COLLAGEN proteins, improving skin and blood vessel health. (1-10,18,19,25,36,37,60)

Flavay® is scientifically documented as a scavenger of the free radicals that play a major role in the degradation of collagen and initiation, duration and breakdown of inflammation.
(1-10,18,19)

Flavay® is especially effective at neutralizing the hydroxyl radical, the superoxide radical, singlet oxygen, and the dangerous chemical peroxynitrate radical, which is produced from interactions between the superoxide radical and nitric oxide. What makes peroxynitrate so dangerous is that it reacts with fats (lipids), proteins (collagen), DNA, membrane, and just about everything. Excessive nitric oxide production is associated with arthritis, asthma, diabetes, stroke, septic shock, chronic inflammation, and atherosclerosis. (1-8,14)

The good news is that Flavay® can neutralize peroxynitrate. It also reduces the amount of superoxide available that makes peroxynitrate and it helps to regulate the nitric oxide production so that it stays in balance. That means your immune system works better, your joints hurt less, and your blood flows better—all because of Flavay®. (1-8)

Below are a few specific examples, which are supported by scientific research. Click the links to learn more.

for your Brain

Flavay® is beneficial to brain function because it readily crosses the blood-brain barrier and enters into the regions of the brain where it provides superior antioxidant protection and improves circulatory efficiency through enhanced vascular strength and elasticity. Flavay’s® antioxidant protection of brain cells is significant as recent studies have established a connection between free radical damage and cognitive impairment.
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for your Immune System

Flavay® helps in various ways to normalize immune function at the cellular level. First, Flavay® has the power to restore cytokine imbalances and can normalize white blood cell activity, thereby boosting immune function. Also, Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses, and host parasites. Finally, by recycling the activity of vitamins C and E—key players in the body's immune system—Flavay® helps the body to maintain its natural antioxidant defenses, giving the body more ammunition to fight infection.
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for your Cardiovascular System

Flavay® provides the nutritional support necessary for the maintenance of a healthy heart. Through reducing platelet aggregation, strengthening vascular membranes, and safeguarding against cellular destruction, normal blood flow is supported and maintained.
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for your Circulatory System

Healthy blood flow is essential to human health and life. Flavay® promotes a healthy circulatory system by strengthening capillary walls and micro-capillaries and improving capillary resistance and reducing leakage.
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for your Eyes

Through supporting the body's overall circulatory function, Flavay® enhances visual adaptation of the eye to different light environments. It also provides nutritional support in protecting the health of the retina. Licensed and sold for eye health in France, the vascular protective activity of Flavay® has been established by many significant studies.

In clinical trials of patients with various types of retinal diseases, including macular degeneration, diabetic retinopathy, retinitis pigmentosa, and hemorrhagic and hypertensive retinopathy, all persons given Flavay® showed significant improvement. (3,8)
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for your Legs

Edema and Inflammation

Flavay® helps to improve capillary strength and reduces capillary leakage. It also helps support the body in maintaining healthy circulatory function in leg veins.

Italian scientists from the University of Florence studied the effect of Flavay® on venous congestion (edema) in the legs. The study involved 40 subjects consisting of 13 men and 27 women between the ages of 34 and 74. The subjects were randomly divided into two groups. One group received a placebo and the other group received 300 mg of Flavay® daily for 60 days.

All of those taking the Flavay® had relief from at least some of the symptoms. After 30 days, the pain was totally relieved in in 38 percent of those taking Flavay®, the swelling disappeared in 26 percent (the circumference of the legs was measured above the ankle), and 11 percent experienced a decrease in the feeling of heaviness in their lower limbs. After 60 days, the pain was totally relieved in 67 percent of those taking Flavay®, the swelling disappeared in 63 percent, and the decrease in heaviness jumped to 33 percent. (3,8)
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for your Joints

Flavay® can selectively bind to the connective tissue of joints, preventing inflammation and lessening pain. And, the nutrients in Flavay® can be considered as 'collagen vitamins' because they partake in the biosynthesis of collagen and prevent its destruction.
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for your Lungs

Flavay® has been successfully used for controlling hay fever and allergies for many decades. Research now shows several ways that Flavay® may influence the immune response to help normalize the balance of chemicals in the body that control inflammation and allergies.
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for your Skin

Visible signs of weak collagen are wrinkles and sagging skin. Flavay® works to strengthen and rebuild collagen. Through preserving the body's natural collagen proteins, Flavay® enhances the elasticity of skin, helping to offset visible signs of premature aging.
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for Anti-Aging

Flavay® neutralizes the free radical reactions that are responsible for the progressive deterioration of biological systems, including the brain. It is 100% bioavailable and its high free radical scavenging effect is believed to be associated with a longer, healthier, life with an increased functional life span. Flavay® protects against the breakdown of skin collagen, a process that produces visible signs of aging.
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for Sports Activities and Recovery

Flavay® strengthens the body's collagen which is a major component of muscles, tendons, cartilage, ligaments and bones. Since Flavay® strengthens collagen, it can be helpful in minimizing damage potential and reducing the recovery time from sports-related activities. It can enhance the body's recovery following strenuous workouts.
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for Advanced Antioxidant Activity

Unlike other antioxidants and bioflavonoids, Flavay® can penetrate both aqueous and lipid cellular membranes. This super-antioxidant possesses greater free radical scavenging capacity than other known antioxidants such as Vitamin C and E. Flavay® works to protect, support and restore the potency of Vitamins E & C as they work in the body. Flavay® is the product—used in the actual experiments—by which Dr. Jack Masquelier established and scientifically documented the "radical scavenger effect."
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