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Flavay® helps to normalize your immune system
Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses and parasites.
A strong immune system is the cornerstone of good health as it protects your body against disease. There are several important ways that Flavay® can nourish and invigorate your immune system. First, Flavay® helps to normalize immune functions at the cellular level. Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses and parasites. However, if nitric oxide is overproduced it turns on its host and damages the macrophages—thereby impairing immune function. Thus, phrases such as "double-edged sword" are frequently applied to nitric oxide in health and disease. This emphasizes the importance of another way that Flavay® benefits the immune system: regulating nitric oxide in the body. Research shows that Flavay® can help to maintain the optimal level of this free radical by helping the body to produce adequate levels—and to neutralize nitric oxide where it does harm.
Finally, by increasing the activity of vitamins C and E in the body, Flavay® helps the body maintain its antioxidant defenses, giving the immune system more ammunition to fight infection.
How Your Immune System Works
Although it's called a "system," the immune system is not associated with one particular organ but it's a collection of cells that "speak" to one another—and with the rest of the body— through chemical messengers (the immunotransmitters) and thereby work in close harmony to protect the body from the harmful effects of bacteria, viruses, parasites and environmental toxins.
Macrophages are the immune system's foot soldiers, capable of engaging in hand-to-hand combat as they literally gobble up invaders to destroy them.
The most important components of the immune cells are the white blood cells (lymphocytes), which include T-cells, B-cells and macrophages. Macrophages are the immune system's foot soldiers, capable of engaging in hand-to-hand combat as they literally gobble up invaders to destroy them.
The white blood cells depend upon immunotransmitters called "cytokines" to communicate with one another and to coordinate their ferocious activity. Cytokines are to the immune system what neurotransmitters are to the brain. Just as the brain relies upon neurotransmitters to exchange information among its neurons and with the rest of the body, so your immune system depends upon cytokines.
When your body is threatened by an invasion, cytokines signal your immune system to mobilize reserve troops of white blood cells. When the invasion is over, your cytokines are responsible for sending the signals to stop mobilizing the troops. In other words, these immunotransmitters coordinate your white blood cells, boosting their activity at times of infection, injury, or other demands and reining them back in after battle.
Flavay® Normalizes Immune Cell Functions and Actually Boosts Immune Function
Flavay® can restore cytokine imbalances and thereby normalize white blood cell activity—normalizing immune function.
When the body fights off an infection, the cytokines go to work, sending messages to the brain that cause more white blood cells to mobilize. The more white blood cells your body activates, the more free radicals they produce. These free radicals are among your immune system's most powerful weapons, as a response to injury and during times of disease, emotional stress and aging. Research demonstrates that Flavay® has the power to restore cytokine imbalances and can normalize white blood cell activity, thereby normalizing immune function.
Flavay® Scavenges the Body's Terrorists: Rampaging Free Radicals
Free radicals are like pellets of poison that destroy invaders by interfering with their cellular machinery, literally dissolving or breaking down the genetic material of bacteria, toxins and viruses.
When all is going well, the immune system is capable of identifying foreign invaders such as viruses and bacteria by accurately "reading" molecular codes found on cell surfaces. These molecular codes are like flags of different armies, and the immune system will not attack a cells if it "reads" a flag belonging to the body's own host army. Unfortunately, however, free radicals can interfere with the biological components of our healthy cells, just as they destroy invaders. This leads to many diseases.
Nitric Oxide Toxicity and Abnormal Immune Responses
Contemporary research shows that elevated levels of nitric oxide appear to contribute to arthritis and other disorders associated to abnormal immune responses.
Contemporary research shows that elevated levels of nitric oxide (sometimes referred to as "NO") appear to contribute to a number of seemingly different disorders that all have a common element of abnormal immune or inflammatory responses.
Studies of arthritis, colitis, and other inflammatory disorders have all demonstrated elevated levels of nitric oxide synthesis. In the case of arthritis, nitric oxide has been implicated in the destruction of the pericellular and extracellular matrix of cartilage in arthritis.
Arthritis is an umbrella term for more than 100 different conditions that produce either inflammation of connective tissue (joints and tendons) or degeneration of the articular cartilage, a wearing down of the protective covering that cushions the ends of bones, allowing bones to rub together without causing damage to the joints.
When joints become arthritic, they become inflamed and enlarged, interfering with the normal flow of blood. For example, when you bend an arthritic knee, you cut off blood flow to the area which sets into motion of a chain of events that will lead to a burst of free radicals when the blood flow returns (known as "reperfusion injury"). When you release the knee, a proliferation of free radicals causes the area to become even more inflamed, contributing to the degeneration of the joint, which becomes more swollen and worn down.
High levels of nitric oxide have also been implicated in the inflammation that is associated with asthma. Asthmatics exhale significantly higher levels of nitric oxide and type II nitric oxide synthase (also known as "NOS") expression is increased in biopsy specimens from asthmatics.
It's long been recognized that nitric oxide is essential for normal blood circulation as it controls the muscular tone of blood vessels and regulates circulation and blood flow. However, excessive amounts of nitric oxide can be deadly to the cardiovascular system and actually contribute to disease and inflammation. High levels of nitric oxide can restrict blood flow and promote production of more free radicals, including the dangerous peroxynitrate.
Flavay® can help regulate a healthy balance of nitric oxide in the body.
Flavay® can significantly scavenge nitric oxide radicals. However, as we'll discuss next, your body needs a certain amount of nitric oxide in order to maintain good health. Nitric oxide is paradoxical. It can both mediate normal physiological functions and it can be highly toxic. Nitric oxide can act as an anti-inflammatory under normal health conditions, but it can have the opposite effect and cause more inflammation to an already inflamed area when overproduced. The key, therefore, is to maintain the optimum balance of this double-edged sword, nitric oxide.
When the immune system's cytokines activate macrophages (the white blood cells capable of gobbling up invading viruses and bacteria), the macrophages produce large amounts of nitric oxide in the course of battle. Nitric oxide is a colorless gas produced by many different cells in the body that, depending on the situation, can be very good or very bad. Nitric oxide plays several important roles in the body:
But nitric oxide can be very destructive under other circumstances:
The real trouble starts when nitric oxide encounters the superoxide free radical and becomes peroxynitrate, which destroys antioxidants like glutathione, vitamin E and common flavonoids, and damages proteins in the body. The good news is that Flavay® scavenges peroxynitrate and has a remarkable modulatory effect on nitric oxide—helping to maintain optimal levels in the body and neutralizing this free radical where it does harm.
Flavay® is the actual product—used in the experiments—by which Dr. Jack Masquelier patented the "radical scavenger effect."
"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischaemia, alterations of the synovial liquid, collagen degradation, among others. The method consists in administering to said animals and especially to human beings an amount, efficient against said effects, of a plant extract with a proanthocyanidins content which has a radical scavenger effect"—U.S. Patent No. 4,698,360 (1987).
Flavay® is the product—used in the actual experiments—by which Dr. Jack Masquelier patented the "Radical Scavenger Effect." of Flavay®
Flavay's® strong antioxidant power acts as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation. That means that your immune system works better, your joints hurt less, and your blood flows better, all because of Flavay®.
Flavay Increases the Activity of Vitamins C and E
Flavay® recycles and significantly extends the lifetime of vitamin C and potentiates vitamin E, and thereby creates a more powerful, synergistic antioxidant defense in the body. This is important because vitamins C and E are key players in the body's protective antioxidant army.
Antioxidants fight corrosive and destructive forces that constantly work to break down our bodies. Overwhelming scientific evidence demonstrates that those of us who eat a diet rich in antioxidants and take antioxidant supplements will live longer and healthier lives. Working as a defensive army, antioxidants work together in the body to maintain our health and vigor by protecting us from damage caused by rampaging free radicals which, like terrorists, injure healthy cells and tissues.
Don't underestimate the threat that free radicals pose to our health. Contemporary scientists now believe that free radicals are causal factors in nearly every known disease, from heart disease to arthritis to Parkinson's to Alzheimer's to ALS to multiple sclerosis to cataracts to the aging process itself.
As a free radical scavenger, Flavay® is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.
As a free radical fighter, Flavay® comes to the aid of the body more quickly than other antioxidants, reducing the potential for free radical damage and the ravages of aging. Flavay® also possesses more reactive sites for neutralizing free radicals than other known antioxidants. Furthermore, Flavay® permits reactivity with both positively and negatively charged free radical species. What this means is that Flavay® can quench or scavenge (neutralize) a broad variety of free radicals. Highly reactive as an antioxidant in both lipid (fat) and aqueous (water) phases, Flavay® neutralizes oxygen free radicals and is a valuable protector of healthy cells in a variety of internal conditions. This is a unique property among antioxidants, as most work either in lipid or aqueous phases, but not both. As a free radical scavenger, Flavay® is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.
Flavay®: More Than 60 years of Protection
Now available in the United States, Flavay® is the actual polyphenol that has been licensed and sold in France since 1950. And, Flavay Plus® utilizes the dynamic interplay between Flavay® and the other antioxidant nutrients and their co-factors in order to provide you and your family with the best that nutritional science has to offer for immune protection—in a convenient, cost effective capsule.
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|Masquelier, J. A lifetime devoted to OPC and [pyc]. Alfa Omega Editrice, Pub., 1996. Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice, Publishers, 1995. Lombard, J., Germano, C. The brain wellness plan: breakthrough medical, nutritional and immune-boosting therapies to prevent and treat: depression, Alzheimer's disease, chronic fatigue syndrome, attention deficit disorder, multiple sclerosis, Parkinson's disease, Lou Gehrig's disease. Kensington Pub. Corp., 1998. Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats Publishing, Inc., 1997. Packer, L., et al. The antioxidant miracle: your complete plan. John Wiley & Sons, Inc., 1999. Packer, L., et al. Antioxidant food supplements in human health. Academic Press, 1999. Lincoln, J., Hoyle, C.H.V., Burnstock, G., Nitric oxide in health and disease. Cambridge University Press, 1997. Moncada, S., Nistico, G., Bagetta, G., Higgs, E.A. Nitric oxide and the cell. Princeton University Press, 1998. Facino, R.M., et al. Free radical scavenging action and anti-enzyme activities of procyanidines from vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung, 44: 592-601, 1994. Passwater, R.A. The antioxidants: the nutrients that guard your body. Keats Publishing, Inc., 1985. Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants. Keats Publishing, Inc., 1995. Facino RM, et al. Free radical scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung, 44: 592-601, 1994. Kuttan R, et al. Collagen treated with catechin becomes resistant to the action of mammalian collagenase. Experientia, 37: 221-223, 1981. Masquelier, J., et al. Stabilization du collagene par les oligomeres procyanidoliques. Acta Therapeutica, 7:101-105, 1981. Masquelier, J. Aspects pharmacologiques nouveaux de certains flavonoides. A Vie Medical 12:1969. Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques totaux du raisin. Acta Therapeutica, 4, 1978. Laparra, J., et al. Etude pharmacocinetique des oligomeres flavonoliques. Plantes med et phyto, Tome XI, pp. 133-142, 1977. Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de laction des oligomeres procyanidoliques sur des cellules mesenchymateuses en culture. Ii lattachment des fibres elastiques aux cellules. (Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990. Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and crystal structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3, 4.4, 5.7-Hexahydroxyflavan] dihydrate, and comparison of its heterocyclic ring conformation in solution and the solid state. Journal of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17. Masquelier, J. Proanthocyanidins et radicaux libres. 1985. Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals. Med Sci Res, (15) 1987. pp. 831-832. Ariga, T. Radical scavenging action and its mode in procyanidins b-1 and b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990. pp. 2499-2504. Da Silva, R., et. al. Radical scavenger capacity of different procyanidins from grape seeds. Presented at a symposium, Free radicals in biotechnology and medicine. Royal Society Of Chemistry, London January 1990, pp. 79-80. Bauman, J., Wurm, G., Bruchhausen, F. Hemmung der prostagladinsynthetase durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften Arch Pharm, (Weinheim) 313 (1980) pp. 330-337. Flesch M., et al., Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:1183-94. Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM. Isolation and characterization of endothelium-dependent vasorelaxing compounds from grape seeds. J Agr & Food Chem In press. Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation, endothelium, and wine. BioFactors 1997;6:455-459. Fitzpatrick, D.F., Hirschfield SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol 1995;26:90-95. Fitzpatrick, D.F., Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Amer J Physiol 1993;265:H774-H778. Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with catechin becomes resistant to the action of mammalian collagenase. Experientia, 37: 221-223, 1981. Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95: 89-97, 1990. Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding of [pyc] to elastin affects its rate of degradation by elastases. Biochem Pharmacol, 33: 3933-3939, 1984. Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985. Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted from vitus vinifera l. in the rat. European Journal of Drug Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30. Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging activity of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo and in vitro study. Cosmetology Department & S Biovectors, Ramonville St. Agne France. pp. 1-9. Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica, May 26, 1986. pp. 12-15. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques chez lanimal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques chez lanimal-activite aniagoniste vis-a-vis des mediateurs de linflamation. Sanofi Res Toul Cedex Fr, pp. 31-40. Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire, spontanement ou artificiellement diminuee par laction dune substance capillaro-toxique chez des personnes agees--action benefique dun agnet actif sur la micro-circulation: lEndotelon. Inform. Therapeut. 1980. pp. 302-305. Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude dun microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990. Lagrue, G., Olivier-Martin, F., Grillot, A. Etude des effets des oligomeres du procyanidol sur las resistance capillaire dand lhypertension arterielle et certaines nephropathies. Sen. Hosp. Paris 18-25 Septembre, 1981. Beylot, C., Bioulac, P. Essai therapeutique dun angioprotecteur peripherique, lEndotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24, 1980. Lesbre, F.X., Tigaud, J.D. Effect de lEndotelon sur lindice de fragilite capillaire dan une population specifique: les sujets cirrhotiques. Gaz. Med. de France, (90)24 1983. Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs par un microangioprotecteur lEndotelon. Bordeaux Med, 11:685-8, 1981. Delacroix, P. Etude en double aveugle de lEndotelon dans linsuffisance veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981. pp. 1793-1802. Thebaut, J.F, Thebaut, P., Vin, F. Etude de lEndotelon dand les manifestations fonctionnelles de linsuffisance veineuse peripherique-resultats dune etude en double aveugle portant sur 92 patients. Gazette Medicale, (92)1, 1985. pp. 96-100. Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty Acids, 38:181-8, 1989. Masquelier, J. [pyc]: recent advances in the therapeutical activity of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant Research and Journal of Natural Products, July 1980 pp. 243-256. Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106. Masquelier, J. Les procyanidols du vin leur role dans lalcoolisme. pp. 88-93. Gazave, J.M. Notions recentes sur les capillaires unpub. bulletin from the Laboratoire De Physiologie Patholigie pp. 26-29. Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis. Office International Vigne et du Vin, Nutrition and Health Unit, Paris France; Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131), 1999. Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980. Tayau, M.F, LeFevre, G. Action du leucocyanidol sur lhyalaluronidase. Bull Soc Pharm Bordeaux, 95:132-136, 1956. Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie. Essai Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22. Henriet, J.P Une Etude Exemplaire Pour Un Phlebotrope: letude EIVE. Unpub., pp. 77-83. Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye. Acta Therapeutica (8) 1982. pp. 223-237. Kuttan, R., Donnelly, P., Di Ferrante, N. Collagen treated with (+) -catechin becomes resistant to the action of mammalian collagenase. Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col. of Med., Houston TX. 28, May, 1980. Gendre, P., Laparra, J., Barraud, E. Effect protecteur des oligomeres procyanidoliques sur le lathyrisme experimental chez le rat. Ann. Pharm. Francaises, (43)1, 1985 pp. 61-73. Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr. Opthalmol, (11)5:453-460, 1988. Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and dazzling: use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4, 177-9, 1988. Proto, F. et al. Electrophysical study of vitis vinifera procyanoside oligomers effects on retinal function in myopic subjects. Ann Ott Clin Ocul, 114:85-93, 1988. Saracco, J.B., Estachy, G.M. Etude d lEndotelon en opthalmologie. Gaz Med de France, 88:2035-2038, 1981. Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies. Klin Monatsbl Augenheilkd, 178:386-389, 1981. Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol, 11:453, 1988. Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C. Bordeaux Medicale, (16)11. pp. 1467-74, 1978. Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology. Bull Soc Ophtalmol Fr. 87(12):1441-4, 1987. Fromantin, M. Les oligomeres procyanidoliques dans le traitement de la fragilite capillaire et de la retinopathie chez les diabetiques. A propos de 26 cas. Med Int, 16(11):432-434, Nov. 1981. Arne, J.L. Contribution a letude des oligomeres procyanidoliques: Endotelon, dans la retinopathie diabetique (a propos de 30 observations). Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982. Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5, 1984. Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981. Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica, 9:355-374, 1972. Havsteen, B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol, 32:1141-48, 1983. Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977. Masquelier, J. Action protectrice du vin sur lulcere gastrique. Resultats, p. 61. Amella, M., et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica, 5116-20, 1985. Shaw, R. How [Australian] [pyc] [MASQUELIERs®] Helps Sports People. Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet Arom 95:89-97, 1990. Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques (Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members superieurs. Symposium Satellite, Congres International dAngiologie, Toulouse, France, 4-7 Oct. 1989. Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks of intense training. Abstract submitted to national meeting of the Amer College of Sports Medicine, June 1998. Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm 43: 385388, 1992. Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Bio of Sport 15(3):135-44, 1998. Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux, 1976. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur loxydation de lacide ascorbique par les ions cuivriques. Bull. de la Societe de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur lacide ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4) 1951. pp.304-306 Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka, I. Inhibitory effects of tannins on hyaluronidase activation and on the degranulation from rat mesentery mast cells. Chem. Pharm. Bull. 33(11)1985. 5079-5082. Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Dirkhauser Verlag,Vol. 7/1, 1977. Pariente, J.J. Parientl-Amsellem, J. Les oedemes post-traumatoqies chez le sportif: essai controle de lEndothelon. Actualite Therapeutique 90(3) 2/11 1983 pp. 231-235. Masquelier, J., et al. Flavonoids et [pyc] Int J Vit Nut Res, (49)3:307-311, 1979. Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol. 25(2):135-9, 1987. Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica Report, 1971. Laparra, J., et al., Acta Therapeutica, 4:233, 1978. Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells of the mouse with [pyc]. Cytotest Cell Research GmbH & Co., projects 143010 & 143021; Feb. 1989. Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover, Germany, 1967-1971. Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990.|