Flavay’s® action is synergistic for athletes: it protects the body by helping neutralize the naturally occurring pro-oxidative effects of strenuous workouts, and strengthens the body’s collagen, which is a major component of muscles, tendons, cartilage, ligaments and bones.

A Completely Safe, Non-Drug, Natural Approach to Accelerate Recovery Time from Strenuous Workouts and Sports Injuries

Flavay® can help minimize damage and accelerate recovery time from strenuous workouts, sports-related activities and postoperative inflammation.

Flavay® has been licensed and sold in France for treating inflammation and edema (swelling) since 1950 and is now available in the United States as a dietary supplement. Research shows several ways that Flavay® can help minimize damage and accelerate recovery time from strenuous workouts and sports-related activities.

Flavay’s® action is synergistic for athletes: it protects the body by helping neutralize the naturally occurring pro-oxidative effects of strenuous workouts, and strengthens the body’s collagen, which is a major component of muscles, tendons, cartilage, ligaments and bones.

Flavay’s® ability to strengthen and rebuild collagen is important to injury-recovery because most athletic injuries involve damaged capillaries (tiny blood vessels), caused by torn muscles, sprains, fractures or twisting and whiplash. Strengthening of the vascular walls in the capillaries prevents fluids from seeping and swelling in the connective tissues. These types of injuries are painful and usually cause other problems, such as a loss in physical condition when the injury causes an inability to train or compete.

In an Australian study conducted on injured soccer players, those that consumed Flavay® experienced significantly less swelling than those who did not.

Research has shown that Flavay’s® ability to strengthen vascular walls may help the body to repair injuries faster. In an Australian study conducted on two groups of soccer players that had sustained injuries, those that consumed Flavay® for ten days following their injuries experienced significantly less swelling than those who did not and, in some of those taking Flavay®, the swelling had completely disappeared. Other research has demonstrated the ways in which Flavay® may actually inhibit inflammation including double-blind studies conducted in France which showed that Flavay® can also reduce postoperative inflammation.

Natural Anti-Inflammatory

Inflammation is caused by the overproduction of free radicals in a specific area of the body. We now know that antioxidants work together to defeat free radicals and inhibit the biological pathway that triggers inflammation, and Flavay® is particularly effective as an anti-inflammatory.

Flavay® can selectively bind to the connective tissue of joints, preventing inflammation and lessening pain.

Flavay® can selectively bind to the connective tissue of joints, preventing inflammation and lessening pain. One of the very first benefits observed and studied Dr. Jack Masquelier, in as early as 1947, was the anti-inflammatory effect of Flavay®.

Research demonstrates that Flavay® inhibits the release and synthesis of histamine (which produces accelerated blood flow, dilates capillaries and increases their permeability, thereby leaking plasma into surrounding tissue), a key factor in the promotion of inflammation.

Studies demonstrate that the anti-histamine action of Flavay® is obtained through inhibiting the activity of the enzyme histidine decarboxylase. Dr. Masquelier’s research has been confirmed by German studies which show that Flavay® may lower the production of histamine with as much as 86% inhibition of histidine decarboxylase.

Flavay® also neutralizes free radicals that promote swelling and cause inflammation. A free radical called superoxide is involved in the inflammation of arthritis and several experiments show that Flavay® quenches the superoxide free radicals.

Edema (Swelling)

Edema is an uncomfortable condition and can be both painful and dangerous. Swollen and painful legs and ankles, puffiness of the eyes and an overall bloated look and feel are examples of edema. It involves the leakage of blood serum into surrounding tissues and Flavay® has shown that it can reduce this leakage by strengthening capillary walls.

All of those taking Flavay® for edema (swelling) had relief from at least some of the symptoms.

Italian scientists from the University of Florence studied the effect of Flavay® on venous congestion (edema) in the legs. The study involved 40 subjects consisting of 13 men and 27 women between the ages of 34 and 74. The subjects were randomly divided into two groups. One group received a placebo and the other group received 300 mg of Flavay® daily for 60 days.

All of those taking the Flavay® had relief from at least some of the symptoms. After 30 days, the pain was totally relieved in in 38 percent of those taking Flavay®, the swelling disappeared in 26 percent (the circumference of the legs was measured above the ankle), and 11 percent experienced a decrease in the feeling of heaviness in their lower limbs. After 60 days, the pain was totally relieved in 67 percent of those taking Flavay®, the swelling disappeared in 63 percent, and the decrease in heaviness jumped to 33 percent.

Flavay's® strong antioxidant power acts as a scavenger of the free radicals that play a major role in the initiation, duration and breakdown of inflammation and the degradation of collagen.

"[A] method for preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumour promotion, inflammation, ischaemia, alterations of the synovial liquid, collagen degradation, among others. The method consists in administering to said animals and especially to human beings an amount, efficient against said effects, of a plant extract with a proanthocyanidins content which has a radical scavenger effect"—U.S. Patent No. 4,698,360 (1987).

Flavay® is the product—used in the actual experiments—by which Dr. Jack Masquelier patented the "Radical Scavenger Effect." of Flavay®
This means that your immune system works better so that your joints hurt less and your blood flows better—all because of Flavay®.

Sports and Exercise Increase the Body's Need for Antioxidants

Exercise increases the body's need for antioxidants.

Exercise is extremely beneficial, but many do not realize that exercise increases the body's need for antioxidants. The fuel our bodies require for sports and exercise is oxygen. Yet the body's production of energy from oxygen can also wreak havoc in the body because it produces free radicals. If we are deficient in antioxidants, the benefits of exercise are diminished by the damage caused by free radicals. Thus, the key to good health, is to maintain the right balance between antioxidants and free radicals. It's not surprising, therefore, that studies have suggested that antioxidants like Flavay® can actually improve athletic performance and endurance.

Superior Antioxidant Support

Flavay® is superior to other antioxidants because its protective effects are multiplied in the body. While it provides its own, powerful antioxidant protection, it also supports the dynamic interplay between other antioxidants in the body. Flavay's ability to “recycle,” or regenerate vitamins C and E after they have quenched free radicals vastly extends their unique antioxidant powers, helping to maintain an optimal, synergistic antioxidant balance in the body.

Flavay® is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.

Flavay® is rapidly absorbed and very quickly distributed throughout the body. As a free radical fighter, Flavay® comes to the aid of the body more quickly than other antioxidants, reducing the potential for free radical damage and the ravages of aging. Flavay® also possesses more reactive sites for neutralizing free radicals than other known antioxidants. Furthermore, Flavay® permits reactivity with both positively and negatively charged free radical species. What this means is that Flavay® can “quench” or “scavenge” (neutralize) a broad variety of free radicals. Highly reactive as an antioxidant in both lipid (fat) and aqueous (water) phases, Flavay® neutralizes oxygen free radicals and is a valuable protector of healthy cells in a variety of internal conditions. This is a unique property among antioxidants, as most work either in lipid or aqueous phases, but not both. Research shows that Flavay® can regulate nitric oxide and quench superoxide and the hydroxyl radical. This is extremely important. Of all the free radicals formed in the body, the hydroxyl radical is the most dangerous because it can directly attack DNA. As a free radical scavenger, Flavay® is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.

Flavay Plus® Adds Synergistic Help for Regulating Stress Hormones

Flavay Plus® is formulated with phosphatidyl serine that—when given to athletes prior to starting exercise—lowered stress hormone (cortisol) production by 30 percent.

Flavay Plus® contains a synergistic blend of Flavay® with antioxidant vitamins, minerals and other phytonutrients to best take advantage of the dynamic interplay among the antioxidants and their co-factor nutrients. Of particular interest is phosphatidyl serine, as research has shown that it may have the capacity to normalize the stress-induced activation of the above-described, "fight or flight response."

Phosphatidyl serine: Flavay Plus® is formulated with phosphatidyl serine (Leci-PS™), a complex of amino and fatty acids extracted from soy lecithin, which has proven to be a safe, potentially effective therapeutic agent in keeping the brain’s processes within normal limits, raising them when they are low and lowering them when they are high. Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. Phosphatidyl serine given to athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones. Phosphatidyl serine may have the capacity to normalize the stress-induced activation of the "fight or flight response." In a double-blind, placebo-controlled study conducted in Italy, phosphatidyl serine lowered stress hormone (cortisol) production by 30 percent.

Two more recent placebo controlled studies confirmed earlier double-blind trials; young, university students experienced significantly less stress from tests when they took phosphatidyl serine (300 mg daily for 30 days), they stayed more clear-headed and composed, and kept a more stable mood.

Proven Safety of Flavay®

After more than 60 years of human use, no adverse effects have been observed. Furthermore, intensive biological, toxicological, pharmacological and analytical research was conducted for the purpose of registering it as a medicine in France and other countries in Europe. In one study, daily doses of up to 35,000 mg for six months were determined to cause no adverse effects. Flavay® was also clinically tested, in particular for all sorts of symptoms related to venolymphatic insufficiencies (strenghthening veins, improving circulation and reducing edema and inflammations). The spin-off is a goldmine of data: The rigorous testing to meet the standards required by the health ministries of France, Germany and other European countries demonstrate that Flavay® is highly bioavailable, nontoxic, nonallergenic, noncarcinogenic, nonmutagenic, will not cause birth defects, and is completely safe.

Dr. Masquelier’s unequaled manufacturing process has been conducted for half a century at the very same facilities in France, and under the control of French Pharmaceutical inspection. These time-proven standards serve as a reliable assurance of the quality, consistency, bioavailability and safety of Flavay®.

Who can take Flavay®?

Everyone, from the very young to elderly. Flavay® has no known contraindications (conditions under which it should not be used). Flavay® is completely safe and nontoxic. In fact, clinical trials have been conducted in which pregnant women (troubled by varicose veins and other circulatory problems in the legs) safely used Flavay®.

Safety of Flavay®Plus®

The essential vitamins and minerals in Flavay Plus® are naturally-derived and completely safe. Flavay Plus® includes phosphatidyl serine, derived from soy lecithin, which has been proven safe in standard toxicology tests. From the large number of human studies conducted, phosphatidyl serine has developed a flawless safety record and proven compatible with a wide array of medications.

Why Trust Flavay®

Consumers need to know that the marketplace is full of imitations, various “extracts” and derivative forms of Dr. Masquelier’s scientifically proven and perfected complex. Unfortunately, many have even used Dr. Masquelier’s name and research in unauthorized ways to promote illegitimate products.

Flavay® is the name you can trust for the precisely defined active polyphenol complex perfected by the inventor, Dr. Jack Masquelier, validated by the French Ministry of Health and documented by a library of research consisting of many patents and hundreds of scientific papers, articles, doctorate theses, lectures and presentations. For quality, consistency, bioavailability and safety, consumers may rely upon Flavay®.

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REFERENCES: Top
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Etude de l’action des oligomeres procyanidoliques sur des cellules mesenchymateuses en culture. Ii l’attachment des fibres elastiques aux cellules. (Study of the effect of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990. Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and crystal structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3’, 4.4’, 5.7’-Hexahydroxyflavan] dihydrate, and comparison of its heterocyclic ring conformation in solution and the solid state. Journal of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17. Masquelier, J. Proanthocyanidins et radicaux libres. 1985. Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals. Med Sci Res, (15) 1987. pp. 831-832. Ariga, T. Radical scavenging action and its mode in procyanidins b-1 and b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990. pp. 2499-2504. Da Silva, R., et. al. Radical scavenger capacity of different procyanidins from grape seeds. Presented at a symposium, “Free radicals in biotechnology and medicine.” Royal Society Of Chemistry, London January 1990, pp. 79-80. Bauman, J., Wurm, G., Bruchhausen, F. “Hemmung der prostagladinsynthetase durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften” Arch Pharm, (Weinheim) 313 (1980) pp. 330-337. Lombard, J., et al. The brain wellness plan. Kensington Pub. Corp., 1998. Flesch M., et al., Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:1183-94. Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM. Isolation and characterization of endothelium-dependent vasorelaxing compounds from grape seeds. J Agr & Food Chem In press. Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation, endothelium, and wine. BioFactors 1997;6:455-459. 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Evolution de la resistance capillaire, spontanement ou artificiellement diminuee par l’action d’une substance capillaro-toxique chez des personnes agees--action benefique d’un agnet actif sur la micro-circulation: l’Endotelon. Inform. Therapeut. 1980. pp. 302-305. Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude d’un microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990. Lagrue, G., Olivier-Martin, F., Grillot, A. “Etude des effets des oligomeres du procyanidol sur las resistance capillaire dand l’hypertension arterielle et certaines nephropathies.” Sen. Hosp. Paris 18-25 Septembre, 1981. Beylot, C., Bioulac, P. Essai therapeutique d’un angioprotecteur peripherique, l’Endotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24, 1980. Lesbre, F.X., Tigaud, J.D. Effect de l’Endotelon sur l’indice de fragilite capillaire dan une population specifique: les sujets cirrhotiques. Gaz. Med. de France, (90)24 1983. Sarrat, L. 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Contribution a l’etude des oligomeres procyanidoliques: Endotelon, dans la retinopathie diabetique (a propos de 30 observations). Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982. Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5, 1984. Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981. Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica, 9:355-374, 1972. Havsteen, B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol, 32:1141-48, 1983. Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977. Masquelier, J. Action protectrice du vin sur l’ulcere gastrique. Resultats, p. 61. Amella, M., et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica, 5116-20, 1985. Shaw, R. How [Australian] [pyc] [MASQUELIER’s®] Helps Sports People. Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet Arom 95:89-97, 1990. Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques (Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members superieurs. Symposium Satellite, Congres International d’Angiologie, Toulouse, France, 4-7 Oct. 1989. Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks of intense training. Abstract submitted to national meeting of the Amer College of Sports Medicine, June 1998. Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm 43: 385–388, 1992. Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Bio of Sport 15(3):135-44, 1998. Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux, 1976. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur l’oxydation de l’acide ascorbique par les ions cuivriques. Bull. de la Societe de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur l’acide ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4) 1951. pp.304-306 Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka, I. “Inhibitory effects of tannins on hyaluronidase activation and on the degranulation from rat mesentery mast cells.” Chem. Pharm. Bull. 33(11)1985. 5079-5082. Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. “Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro.” Dirkhauser Verlag,Vol. 7/1, 1977. Pariente, J.J. Parientl-Amsellem, J. “Les oedemes post-traumatoqies chez le sportif: essai controle de l’Endothelon.” Actualite Therapeutique 90(3) 2/11 1983 pp. 231-235. Masquelier, J., et al. “Flavonoids et [pyc]” Int J Vit Nut Res, (49)3:307-311, 1979. Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol. 25(2):135-9, 1987. Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica Report, 1971. Laparra, J., et al., Acta Therapeutica, 4:233, 1978. Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells of the mouse with [pyc]. Cytotest Cell Research GmbH & Co., projects 143010 & 143021; Feb. 1989. Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover, Germany, 1967-1971. Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990.
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